Redefining CpG islands using hidden Markov models
نویسندگان
چکیده
منابع مشابه
Redefining CpG islands using hidden Markov models.
The DNA of most vertebrates is depleted in CpG dinucleotide: a C followed by a G in the 5' to 3' direction. CpGs are the target for DNA methylation, a chemical modification of cytosine (C) heritable during cell division and the most well-characterized epigenetic mechanism. The remaining CpGs tend to cluster in regions referred to as CpG islands (CGI). Knowing CGI locations is important because ...
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ژورنال
عنوان ژورنال: Biostatistics
سال: 2010
ISSN: 1465-4644,1468-4357
DOI: 10.1093/biostatistics/kxq005